Research Article
Formulation and Ex Vivo Evaluation of Membrane Permeation Properties of a Mixed Acetaminophen Gel for Rectal Administration
Issue:
Volume 8, Issue 2, December 2024
Pages:
18-23
Received:
3 July 2024
Accepted:
30 July 2024
Published:
20 August 2024
Abstract: The purpose of this work was to evaluate the permeation of a mixed native starch-based gel of Ipomoea batatas (Convolvulaceae), using acetaminophen as a tracer through a rat rectal membrane (ex vivo method). The formulated gel was composed of a 10 g solution of poloxamer 407 at 20% and 2.5 g of glycerolized potato starch. The gel obtained was a smooth, homogeneous mixed gel with no foam, air bubbles or lumps, there was no characteristic odor, and the gel was whitish in color. This gel was characterized at the physicochemical and rheological level by means of the viscosimeter KINEXUS, pH- meter EUTECH and the study of the permeation was carried out by means of the Ussing chamber of horizontal type (the dual chamber). The formulated mixed gel is thermogelling, rheofluidifying and viscoelastic with a gelling temperature of 23.83; the permeation study gave a relatively low permeation percentage of 0.16% but which can be improved. The different viscoelastic, rheofluidizing and thermogelling characteristics contained in this mixed gel as well as the pH did not influence the permeation of the active ingredient (AP) through the rat rectal mucosa.
Abstract: The purpose of this work was to evaluate the permeation of a mixed native starch-based gel of Ipomoea batatas (Convolvulaceae), using acetaminophen as a tracer through a rat rectal membrane (ex vivo method). The formulated gel was composed of a 10 g solution of poloxamer 407 at 20% and 2.5 g of glycerolized potato starch. The gel obtained was a smo...
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Research Article
Formulation and in vitro Evaluation of Liquisolid Compact of Celecoxib
Ezegbe Chekwube Andrew*
,
Anikwe Celestine Chidera,
Okorie James Ekemezie,
Okafor Nnedimma Pauline,
Amarachi Grace Ezegbe,
Nwankwo Emmanuel Chinedu,
Okorafor Ezinne Chinemerem
Issue:
Volume 8, Issue 2, December 2024
Pages:
24-46
Received:
9 June 2024
Accepted:
27 June 2024
Published:
20 September 2024
DOI:
10.11648/j.pst.20240802.12
Downloads:
Views:
Abstract: Introduction: The liquisolid technique presents a promising avenue for enhancing the dissolution rate and bioavailability of poorly water-soluble drugs like celecoxib. This study investigated the formulation and evaluation of celecoxib tablets using this technique. Aim: To formulate and evaluate celecoxib tablets using the liquisolid technique, with the objective of enhancing its dissolution rate and bioavailability. Methods: Celecoxib tablets were prepared using the liquid-solid technique by incorporating a non-volatile liquid medication carrier and a suitable solid carrier. Various formulations were developed by altering the ratios of drug, carrier, and coating materials. The prepared tablets were characterized for their physical properties, drug content uniformity, in vitro dissolution behavior, and compatibility using Fourier-transform infrared (FTIR) spectroscopy. Results: The solubility profile showed that the maximum rate of solubility was recorded in PEG-400 (11.03 ± 0.01) when compared to other non-volatile solvents. The angle of slide, indicated that the excipients used were within the acceptable limit of 33°. The FTIR spectroscopy showed compatibility of the drug and excipients. The results of the SEM showed that spherically-shaped vesicles were formed. Evaluation of the pre-compression parameters indicated that the drug content was highest in batch F-11 hence its optimization (96.1 ± 0.90). The post compression evaluation indicated that the official tests were within the acceptable range for disintegration time (2.25 ± 0.35). The results of the in vitro release studies of the optimized formulation, conventional tablet and reference commercial tablet showed that the amount of drug released increased steadily with time over the 1-hour period. Conclusion: Our findings underscore its viability as a strategy to enhance the therapeutic efficacy of poorly water-soluble drugs, offering promising prospects for pharmaceutical formulation.
Abstract: Introduction: The liquisolid technique presents a promising avenue for enhancing the dissolution rate and bioavailability of poorly water-soluble drugs like celecoxib. This study investigated the formulation and evaluation of celecoxib tablets using this technique. Aim: To formulate and evaluate celecoxib tablets using the liquisolid technique, wit...
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