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Impact of Different Antibiotic Regimens on Patients with Respiratory Tract Infection

Received: 1 June 2021     Accepted: 8 June 2021     Published: 16 June 2021
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Abstract

To assess impact of different antibiotic regimens on patients with respiratory tract infection, we establish a randomized controlled trial for comparison of different antibiotic regimens. From May 2019 to February 2021, we collected valid data from 182 patients in the hospital. This study consisted of 3 steps. First, we invited the patients with respiratory tract infection who meet the inclusion criteria. Also, patients were divided into control group (n=98) and intervention group (n=84) according to the antibiotic regimen they received. Second, we collected the data by questionnaires, including basic patient characteristics, treatment period, treatment cost, and treatment effect. Third, we analyze the data by software. In this study, the less days of treatment period and less payment of treatment in intervention group patient than control group patients, that their results between were significantly different. Also, treatment effect of two antibiotic regimens were similar, that the rates of treatment effective were no significantly different. In summary, we found that the patients who received levofloxacin lactate sodium chloride injection treatment had shorter treatment period and less treatment cost than the patients who received ceftazidime treatment, but their treatment effects were similar.

Published in Pharmaceutical Science and Technology (Volume 5, Issue 1)
DOI 10.11648/j.pst.20210501.15
Page(s) 37-39
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Antibiotic Regimen, Respiratory Tract Infection, Treatment Period, Treatment Cost

References
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[2] Marciano Beatriz E, Holland Steven M. Primary immunodeficiency diseases: current and emerging therapeutics. Front Immunol 2017; 8: 937.
[3] Bell BG, Schellevis F, Stobberingh E, Goossens H, Pringle M. A systematic re- view and meta-analysis of the effects of antibiotic consumption on antibiotic resistance. BMC Infect Dis 2014; 14: 13.
[4] Cassini A, Högberg LD, Plachouras D, Quattrocchi A, Hoxha A, Simonsen GS, et al. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis. Lancet Infect Dis 2019; 19: 56–66.
[5] Gulliford MC, Dregan A, Moore MV, Ashworth M, Staa T van, McCann G, et al. Continued high rates of antibiotic prescribing to adults with respiratory tract infection: survey of 568 UK general practices. BMJ Open 2014; 4: e006245.
[6] Bonilla Francisco A, Khan David A, Ballas Zuhair K, Javier Chinen, Frank Michael M, Hsu Joyce T, et al. Practice parameter for the diagnosis and management of primary immunodeficiency. J Allergy Clin Immunol 2015; 136 (5): 1178–8.
[7] Youngmee Jee, Johan Carlson, Eric Rafai, Kunda Musonda, Giang Huong Tran Thi, Paula Daza, et al. Antimicrobial resistance: a threat to global health. Lancet Infect Dis 2018; 18 (9): 939–40.
[8] Jain S, Williams DJ, Arnold SR, Ampofo K, Bramley AM, Reed C, et al. Community-acquired pneumonia requiring hospitalization among U.S. children. N Engl J Med 2015; 372 (9): 835–45.
[9] Hagedoorn NN, Borensztajn DM, Nijman R, Balode A, von BothU, Carrol ED, et al. Variation in antibiotic prescription rates in febrile children presenting to emergency departments across Europe (MOFICHE): A multicentre observational study. PLoS Med 2020; 17: 1–23.
[10] Pouwels KB, Dolk FCK, Smith DRM, Robotham JV, Smieszek T. Actual versus ‘ideal’ antibiotic prescribing for common conditions in English primary care. J Antimicrob Chemother. 2018; 73: ii19–26.
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[12] McKay R, Mah A, Law MR, McGrail K, Patrick DM. Systematic review of factors associated with antibiotic prescribing for respiratory tract infections. Antimi-crob Agents Chemother. 2016; 60: 4106–18.
[13] Lassi ZS, Das JK, Haider SW, Salam RA, Qazi SA, Bhutta ZA. Systematic review on antibiotic therapy for pneumonia in children between 2 and 59 months of age. Arch Dis Childhood 2014; 99 (7): 687–93.
[14] Carol Kelly, Chalmers James D, Iain Crossingham, Nicola Relph, Felix Lambert M, Evans David J, et al. Macrolide antibiotics for bronchiectasis. Cochrane Database Syst Rev 2018; 3 (3).
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  • APA Style

    Liu Chen, Weijun Jin, Rong Jian. (2021). Impact of Different Antibiotic Regimens on Patients with Respiratory Tract Infection. Pharmaceutical Science and Technology, 5(1), 37-39. https://doi.org/10.11648/j.pst.20210501.15

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    ACS Style

    Liu Chen; Weijun Jin; Rong Jian. Impact of Different Antibiotic Regimens on Patients with Respiratory Tract Infection. Pharm. Sci. Technol. 2021, 5(1), 37-39. doi: 10.11648/j.pst.20210501.15

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    AMA Style

    Liu Chen, Weijun Jin, Rong Jian. Impact of Different Antibiotic Regimens on Patients with Respiratory Tract Infection. Pharm Sci Technol. 2021;5(1):37-39. doi: 10.11648/j.pst.20210501.15

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  • @article{10.11648/j.pst.20210501.15,
      author = {Liu Chen and Weijun Jin and Rong Jian},
      title = {Impact of Different Antibiotic Regimens on Patients with Respiratory Tract Infection},
      journal = {Pharmaceutical Science and Technology},
      volume = {5},
      number = {1},
      pages = {37-39},
      doi = {10.11648/j.pst.20210501.15},
      url = {https://doi.org/10.11648/j.pst.20210501.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.pst.20210501.15},
      abstract = {To assess impact of different antibiotic regimens on patients with respiratory tract infection, we establish a randomized controlled trial for comparison of different antibiotic regimens. From May 2019 to February 2021, we collected valid data from 182 patients in the hospital. This study consisted of 3 steps. First, we invited the patients with respiratory tract infection who meet the inclusion criteria. Also, patients were divided into control group (n=98) and intervention group (n=84) according to the antibiotic regimen they received. Second, we collected the data by questionnaires, including basic patient characteristics, treatment period, treatment cost, and treatment effect. Third, we analyze the data by software. In this study, the less days of treatment period and less payment of treatment in intervention group patient than control group patients, that their results between were significantly different. Also, treatment effect of two antibiotic regimens were similar, that the rates of treatment effective were no significantly different. In summary, we found that the patients who received levofloxacin lactate sodium chloride injection treatment had shorter treatment period and less treatment cost than the patients who received ceftazidime treatment, but their treatment effects were similar.},
     year = {2021}
    }
    

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    AU  - Liu Chen
    AU  - Weijun Jin
    AU  - Rong Jian
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    DO  - 10.11648/j.pst.20210501.15
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    JF  - Pharmaceutical Science and Technology
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    UR  - https://doi.org/10.11648/j.pst.20210501.15
    AB  - To assess impact of different antibiotic regimens on patients with respiratory tract infection, we establish a randomized controlled trial for comparison of different antibiotic regimens. From May 2019 to February 2021, we collected valid data from 182 patients in the hospital. This study consisted of 3 steps. First, we invited the patients with respiratory tract infection who meet the inclusion criteria. Also, patients were divided into control group (n=98) and intervention group (n=84) according to the antibiotic regimen they received. Second, we collected the data by questionnaires, including basic patient characteristics, treatment period, treatment cost, and treatment effect. Third, we analyze the data by software. In this study, the less days of treatment period and less payment of treatment in intervention group patient than control group patients, that their results between were significantly different. Also, treatment effect of two antibiotic regimens were similar, that the rates of treatment effective were no significantly different. In summary, we found that the patients who received levofloxacin lactate sodium chloride injection treatment had shorter treatment period and less treatment cost than the patients who received ceftazidime treatment, but their treatment effects were similar.
    VL  - 5
    IS  - 1
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Author Information
  • Department of Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, China

  • Department of Pharmacy, Huizhou Third People's Hospital, Huizhou City, China

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