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The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers

Received: 11 October 2016     Accepted: 9 February 2017     Published: 1 March 2017
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Abstract

On the basis of the experimental data we suggest that the differences discovered in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostics of primary cancerous growth as well as in estimation of the efficacy of specific cancer treatment. Clinical studies on biological fluids and tumors of 1,495 patients with cancer of the mammary gland, lungs, prostate, ovaries, bladder or digestive tract showed significant changes in physiological concentrations of amino acids which either directly or indirectly regulate processes of antitumor response, oncogenesis, immunogenesis and apoptosis were shown. Our strategy of application of amino acids as medicinal preparations includes a targeted effect on the functional and metabolic relationships which are changed in specific pathology through the effect on the regulatory mechanisms of intermediate metabolic reactions, limiting stages of metabolic flows, utilization of energy substrates and transport systems restricting the processes of amino acids pool formation. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application of their regulatory effects in oncology was discussed.

Published in Pharmaceutical Science and Technology (Volume 1, Issue 1)
DOI 10.11648/j.pst.20170101.14
Page(s) 10-12
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Free Amino Acids, Regulatory Effects, Oncology

References
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[7] Nefyodov LI. et al. Amino acids and their derivatives in tumour tissue from patients with breast cancer treated with Ukrain. Part VI. Drugs Exp Clin Res. -1996. V.22, №3-5.-p. 155-157.
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[13] Ihata, Y., Miyagi, E., Numazaki, R. Amino acid profile index for early detection of endometrial cancer: verification as a novel diagnostic marker. – 2013.- Int. J. Clin. Oncol. V.19, №3.- p.364-372.
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[16] Bruhat, A., Cherasse, Y., Chaveroux, C., et al. Amino acids as reg- ulators of gene expression in mammals: molecular mechanisms. - 2009.- Biofactors.- V35.- №3.- p.249-257.
[17] Ananieva E. Targeting amino acid metabolism in cancer growth and anti-tumor immune response. - 2015.- World J Biol Chem. – V.6.-V4.- 281–289. doi: 10.4331/wjbc.v6.i4.281.
[18] Hong Ma. Plasma free amino acid profiling of esophageal cancer using high-performance liquid chromatography spectroscopy. – 2014.- World J Gastroenterol. – V.20.- №26.- p.8653–8659. doi: 10.3748/wjg.v20.i26.8653
[19] Karavay P. A. Amino acids in Metabolomics: Perspective for the Use of Regulatory effects of Fee Amino Acids in the Creation on their Basis of Infusion Solutions/ Karavay P, Nefyodov L. I., Karavay N.L.//International Journal of Hematology & Therapy, 2016, V 2, № 2, p.1-2. doi: 10.15436/2381-1404.16.10. ISSN: 2381-1404. http://www.ommegaonline.org /article-deta¬ils/850
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    L. Nefyodov, N. Karavay. (2017). The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers. Pharmaceutical Science and Technology, 1(1), 10-12. https://doi.org/10.11648/j.pst.20170101.14

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    ACS Style

    L. Nefyodov; N. Karavay. The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers. Pharm. Sci. Technol. 2017, 1(1), 10-12. doi: 10.11648/j.pst.20170101.14

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    AMA Style

    L. Nefyodov, N. Karavay. The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers. Pharm Sci Technol. 2017;1(1):10-12. doi: 10.11648/j.pst.20170101.14

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  • @article{10.11648/j.pst.20170101.14,
      author = {L. Nefyodov and N. Karavay},
      title = {The Amino Acid Pool: Plastic Substrates, Specific Regulators of Metabolism and Markers},
      journal = {Pharmaceutical Science and Technology},
      volume = {1},
      number = {1},
      pages = {10-12},
      doi = {10.11648/j.pst.20170101.14},
      url = {https://doi.org/10.11648/j.pst.20170101.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.pst.20170101.14},
      abstract = {On the basis of the experimental data we suggest that the differences discovered in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostics of primary cancerous growth as well as in estimation of the efficacy of specific cancer treatment. Clinical studies on biological fluids and tumors of 1,495 patients with cancer of the mammary gland, lungs, prostate, ovaries, bladder or digestive tract showed significant changes in physiological concentrations of amino acids which either directly or indirectly regulate processes of antitumor response, oncogenesis, immunogenesis and apoptosis were shown. Our strategy of application of amino acids as medicinal preparations includes a targeted effect on the functional and metabolic relationships which are changed in specific pathology through the effect on the regulatory mechanisms of intermediate metabolic reactions, limiting stages of metabolic flows, utilization of energy substrates and transport systems restricting the processes of amino acids pool formation. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application of their regulatory effects in oncology was discussed.},
     year = {2017}
    }
    

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    AB  - On the basis of the experimental data we suggest that the differences discovered in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostics of primary cancerous growth as well as in estimation of the efficacy of specific cancer treatment. Clinical studies on biological fluids and tumors of 1,495 patients with cancer of the mammary gland, lungs, prostate, ovaries, bladder or digestive tract showed significant changes in physiological concentrations of amino acids which either directly or indirectly regulate processes of antitumor response, oncogenesis, immunogenesis and apoptosis were shown. Our strategy of application of amino acids as medicinal preparations includes a targeted effect on the functional and metabolic relationships which are changed in specific pathology through the effect on the regulatory mechanisms of intermediate metabolic reactions, limiting stages of metabolic flows, utilization of energy substrates and transport systems restricting the processes of amino acids pool formation. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application of their regulatory effects in oncology was discussed.
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Author Information
  • Department of Biochemistry, Yanka Kupala State University of Grodno, Grodno, Belarus

  • Department of Hyperbaric Oxygenation, Grodno State Medical Hospital, Grodno, Belarus

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